When you use VBox, you really should use the VBox extensions for the guest. The extensions replace the mouse driver with one that interfaces to the host system, so you effectively use the host mouse driver, which makes the OS/2 mouse driver, of choice, totally redundant (it should be REMed). The same is true of the video driver. Use GRADD, and when you replace GRADD.DLL with the one in the VBox extensions, it then uses the host video driver. Adding AMouse, SNAP, or Panaorama, is just a waste of resources, and they don't really do anything.