It might work IF you can get the drivers for the various intel subsystems, video, chipset, lan, wireless lan and so on.
But as one commentator says, why spend that much when you can get a laptop with keyboard and screen for about half the price.
As for the isostick thing, there was something similar a few years ago that only really worked with windows and it appears that this is not much different. Perhaps you couldn't use it for anything OS/2 related.