Hi Andi, interesting error, 4294967299 is exactly 100000000 in hex, likely not a coincidence, though I don't think it is a signness problem, maybe overflow?
Are you still using 38ESR? If so, I'd suggest trying 45ESR. Back up your profile first, it is possible if you revert back to 38ESR, you might have to manually revert Lightning (in extensions IIRC).
As for the port, I don't think the calendar code has been touched besides changing the DLL name to 8.3 format.
Have you looked at the error console when opening Lightning? Perhaps clear it first.
Unluckily, I don't really use calendar besides making sure it works, using gmx.com.
You might also experiment with disabling "Provider for Google Calendar" and "Timezone Definitions for Mozilla"
Searching, I don't really find anything about our old Lightning being slow.
Edit: Might want to test a different theme, probably not the problem. Ideally would be testing a new profile, not easy with your setup unluckily.
You could also go to about:support and look at any preferences that have changed. In TB, Help-->TroubleShooting Information.