Another consideration with large partitions is chkdsk time if a full chkdsk is required, maybe not too bad with a SSD. When I purchased a 2TB USB drive for backup purposes, I created a 1.5 TB partition for backing up OS/2 including a lot of source files, chkdsk would fail due to lack of memory after I backed a bunch of stuff up.
Being USB, a hard crash or whatever meant a full chkdsk.
Which reminds me Dariusz, you posted a bunch of chkdsk flags earlier, could you repost them?