About GPT. It is slightly slower due to the filter. It allows partitions that are aligned correctly, this is important for SSD's etc that use 4KB sectors as ideally the devices sectors and file systems (JFS) should align. Not only somewhat faster but in the case of SSD's, cuts down on wear. Write a one byte file and 4KB gets written. If sectors are not aligned, 8KB actually gets written with house keeping and garbage collection happening twice as often.
With GPT, you can use other partitioning tools and at the worse, have to go back and reassign the drive letter.
You can only boot GPT with UEFI, and you will have to add the GPT filter to older installs to rad the GPT disks
Personally, I have my 1TB NVMe device partitioned GPT with ArcaOS 5.1, a big data partition and Linux on it and my older half a TB SSD partitioned MBR with legacy installs. rEFInd allows me to boot to which ever I choose, with airboot on the MBR device then chain loading.
Edit: ESP is also on the 1TB NVMe device. I did have one on the regular MBR SSD device, which I added to the system after installing 5.1, things got confusing until I wiped that partition. As you found, hiding it is not good enough.