Eric,
I am running AOS 5.1 on a MSI PROB550-VC motherboard, Ryzen 5 5600x, with a Radeon X600 graphics card, SNAP . Mem says 16,355 MB (3,567 MB accessible to system)
The motherboard has one combo type keyboard/mouse PS/2 port. You can plug in a mouse, or a keyboard, but not both, even when using a splitter or y cable. I tried. And after trying the y cable and failing I found other people posting on the net with the same issue with other motherboards. Apparently to use both a keyboard and mouse at the same time (via a y cable) the motherboard has to be built to to accommodate it.
You said you wanted 8 cores. Remember - more cores equals more cost, both in terms of watts, cooling and money. My system at the desktop consumes 62 watts. It consumes 4 watts when not running - unless I turn off the power supply. I have seen a maximum of 130 watts at boot up and when watching a movie on VLC, Compiling small (3.5 mb applications) gets it to 87 watts.
The motherboard/processor/SSD combination works well in OS/2 - with the following conditions/issues.
I believe you can mix GPT and MBR disks in the same machine, but there are considerations when booting.
The alternatives for a 'boot manager" for booting into different disks/partitions are: 1) the boot menu from the bios, 2) the AOS 5.1 GPT boot manager, 3) Airboot. The bios boot menu will boot to either MBR or GPT disks. The AOS GPT boot manager will only boot GPT disks. Airboot will only boot MBR disks. On this machine Airboot does not work with a USB attached keyboard - you have to use a PS/2 attached keyboard. On my Thinkpad T530 with AOS 5.1 Airboot works fine.
On this machine some Windows applications lock up the machine when running in Win-OS/2 seamless mode. They appear to run fine in Win-OS/2 full screen.
Once OS/2 boots up it is fast. However this machine takes longer to boot than my Thinkpad T530.
Finally - I would strongly encourage you to check out Neil's stuff (Blondeguy.com) when going through a make-buy decision. If he has what you need it might save you a considerable about of time in specifying, buying, assembling and troubleshooting a new machine. Plus he list the watts used by various machines you can get an idea of the trade off between cores and electricity usage.