PDN is similar in layout and feel to Photoshop, but some things bother me. Primarily, the lack of function of the RMB in the GUI. Also, it's in desperate need of many of it's plugins, I suggest you get as many as you feel you need. Otherwise, its pretty great. Give it a shot and see if it can work for what you need it to. It does lack a file browser ala Photoshop as far as I know, but maybe a plugin provides that.