Hi there and wellcome to OS2world!
Odin translate windows API:s to OS2 API:s if I got it right, so it is like running a windows program os/2 natively - in theory. There is a limited number of win32 programs that works, so have no great hope, but in fact some run very well. There is a list of programs working and there is probably more, you just got to test. But if you want to get away from the windows world, why not explore os2-eCs software instead? As a former Os2:er you know about hobbes, but also take a look at ecsoft/2, a nice place for software. If you really want to use windows software under eComStation I should rather recommend a virtual PC like Virtual Box , ported by Paul Smedley for eCS.
Hope this is a first answer for you. Personally I think you do the right thing moving to eCS. You'll re-experience the accuracy and responsiveness again - a feeling not compatible with Windows. Wellcome home!